One of the most important indications are positive symptoms in schizophrenia ( 1). The lack of randomized controlled trials with low risk of bias on antipsychotic withdrawal symptoms highlights the need for further research.Īntipsychotics are primarily used in the treatment of psychotic disorders, which are in most cases associated with delusions and hallucinations ( 1). An odds ratio of 7.97 (95% CI, 2.39–26.58 I 2 = 82.7%, P = 0.003) and NNH of 3 was calculated for the occurrence of withdrawal symptoms after antipsychotic discontinuation.Ĭonclusion: Withdrawal symptoms appear to occur frequently after abrupt discontinuation of an oral antipsychotic. The primary outcome, proportion of individuals with withdrawal symptoms after antipsychotic discontinuation, was 0.53 (95% CI, 0.37–0.70 I 2 = 82.98%, P < 0.01). Results: Five studies with a total of 261 individuals were included. We compared a control group with continued antipsychotic treatment in the assessment of odds ratio and number needed to harm (NNH).ĭata Extraction: We followed guidelines by the Cochrane Collaboration, PRISMA, and MOOSE.
The primary outcome was the proportion of individuals with withdrawal symptoms after antipsychotic discontinuation. Studies that did not implement placebo substitution were excluded from analyses. Study Selection: Of the 18,043 screened studies, controlled and cohort trials that assessed withdrawal symptoms after discontinuation of oral antipsychotics were included in the random-effects model.
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We performed a systematic review and meta-analysis concerning occurrence of withdrawal symptoms after discontinuation of antipsychotics.ĭata Sources: We searched the databases CENTRAL, Pubmed, and EMBASE with no restriction to the beginning of the searched time period and until Octo(PROSPERO registration no. Objective: Avoiding withdrawal symptoms following antipsychotic discontinuation is an important factor when planning a safe therapy. 6Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Bezirkskrankenhaus Augsburg, Medical Faculty, University of Augsburg, Augsburg, Germany.5Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.4Institute of Health Economics and Clinical Epidemiology, University Hospital of Cologne, Cologne, Germany.3Department of Emergency Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.2Department of Psychiatry and Psychotherapy, Technical University of Dresden, Dresden, Germany.
Lasse Brandt 1, Tom Bschor 2, Jonathan Henssler 1, Martin Müller 3,4, Alkomiet Hasan 5,6, Andreas Heinz 1* and Stefan Gutwinski 1
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